Generics tend to cost less than brand-name drugs. Zetia can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Zetia. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome. Most of these side effects may go away within a few days or a couple of weeks.
Call your doctor right away if you have serious side effects. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older.
The side effects of Zetia in children are similar to the side effects in adults. You may wonder how often certain side effects occur with this drug , or whether certain side effects pertain to it. As with most drugs, some people can have an allergic reaction after taking Zetia. A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:. Call your doctor right away if you have a severe allergic reaction to Zetia.
Zetia may cause joint pain. Clinical studies looked at Zetia for the treatment of primary hyperlipidemia in adults and in children ages 10 years and older. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition.
In these groups, joint pain occurred in:. However, 0. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints.
Talk with your doctor right away if you have fever or chills with your joint pain. These symptoms can be signs of an infection.
They can recommend treatments that may help with joint pain, or they may recommend a different treatment option for you. Diarrhea is a common side effect of Zetia. Clinical studies involved adults and children ages 10 years and older. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. Talk with your doctor if you experience diarrhea while taking this medication.
They can suggest ways to help relieve this side effect. You may experience muscle problems as a side effect of Zetia. These problems can include muscle pain and muscle weakness , and rarely, muscle breakdown.
You may also have muscle cramps, spasms, or stiffness. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. However, you may still experience muscle problems if you use Zetia alone. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older:. While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine.
These can be signs of rhabdomyolysis muscle breakdown , which is a serious medical condition. If left untreated, it can cause your kidneys to stop working properly. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia.
People who may be at higher risk of this side effect include those who:. Tell your doctor if any of the above apply to you before starting Zetia treatment. These conditions can raise your risk of muscle problems while taking Zetia. However, some people have reported experiencing memory loss when taking statin drugs. Statins are cholesterol drugs that may be taken with Zetia.
They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. Your doctor will likely start you on the typical dosage approved to treat your condition.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. For this purpose, Zetia may be used:. The only FDA-approved dosage of Zetia is 10 mg once a day.
The dosage is the same for all approved uses. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. The dose of Zetia used for children is the same as the adult dose. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Your child can take Zetia with or without food. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Doing this can raise your risk of side effects.
A medication timer may be useful, too. Zetia is meant to be used as a long-term treatment. Zetia may also be used off-label for other conditions. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. Cholesterol is measured in several ways. Total cholesterol consists of:. High cholesterol occurs when you have more cholesterol in your blood than your body needs.
High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. Symptoms of atherosclerosis may include confusion, fatigue lack of energy , trouble breathing , or pain in your chest , arms, or legs.
Zetia is approved to treat different types of high cholesterol. Each type is described below in more detail. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel.
Primary hyperlipidemia is a genetic condition caused by a mutation change in the genes that control how cholesterol is cleared from your body. Primary hyperlipidemia is also called primary high cholesterol. For primary high cholesterol, Zetia is FDA-approved for use in adults and children to decrease levels of:. For this purpose, Zetia is used with a low-cholesterol diet. Zetia can also be used with statin drugs in adults.
Statins are another type of medication used to lower cholesterol. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo a treatment with no active drug. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. Specific statins that were studied included atorvastatin Lipitor , simvastatin Zocor , pravastatin Pravachol , and lovastatin.
A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia HeFH. The children took Zetia and simvastatin or simvastatin alone. At the end of the study, researchers found that:.
Mixed hyperlipidemia is a genetic condition caused by a mutation change in the genes that control how cholesterol and fats are cleared from your body. Mixed hyperlipidemia is also known as mixed high cholesterol. For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. It can be taken with or without fenofibrate in adults. Fenofibrate is a drug used to lower your triglyceride levels.
In clinical studies , Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo a treatment with no active drug. Homozygous familial hypercholesterolemia HoFH is a rare genetic condition caused by a mutation change in the genes that control how cholesterol is cleared from your body.
For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin Lipitor or simvastatin Zocor in adults and in children ages 10 years and older. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. In the study :.
Homozygous sitosterolemia is a genetic condition caused by a mutation change in the genes that control how plant sterols are cleared from your body. Plant sterols are similar to cholesterol. People with this condition have high levels of plant sterols. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol.
For this purpose, Zetia is used with a low-cholesterol diet but with no other drugs in adults and in children ages 10 years and older. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone.
In clinical studies that lasted 8 weeks, Zetia was compared with a placebo a treatment with no active drug. In the studies:. Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet:.
Zetia belongs to a class of drugs called cholesterol absorption inhibitors. A class of drugs is a group of medications that work in a similar way. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. Statins lower cholesterol by preventing your liver from making new cholesterol. Your doctor may prescribe Zetia with a statin drug. If you have questions about the differences between Zetia and statin drugs, talk with your doctor.
Yes, there are a few. Serum lipid profile was estimated using autoanalyzer. The Institutional Animal Ethics Committee permission was taken before performing the experiment.
After data collection it was entered in Microsoft Excel sheet and validated. Then the generated clean data sheet was copied into SPSS version Analysis was done in SPSS version Paired and unpaired t test were used for assessing the statistical significance. For the experiment for analyzing the lipid lowering effect of Ezetimibe and Atorvastatin in different doses and the combination of both drugs, total 60 rats were used.
The comparative effects between different groups were analyzed using one way analysis of variance ANOVA test. The levels of different blood lipid parameters in 12 weeks were compared. High density lipoprotein HDL cholesterol is considered to be good cholesterol for health.
Its high level is good for health. But among the different treatment groups its level was not significantly different; i. It is clear that in control group fed on atherogenic diet without receiving any drug the total cholesterol, LDL cholesterol and triglyceride continued to be increased and the HDL cholesterol continued to be decreased throughout the 12 weeks time period.
But in all other groups treatment was started at 4 weeks. So, up to 4 weeks the trend of change of different lipid parameters were like control group.
But in these groups it is seen that after 4 weeks the blood level of total cholesterol, LDL cholesterol and triglyceride decreased and HDL cholesterol increased. ANOVA showing comparison of total cholesterol value at 12 weeks between different treatment groups.
ANOVA showing comparison of triglyceride value at 12 weeks between different treatment groups. Unpaired t test showing comparison of HDL cholesterol value at 12 weeks between different treatment groups. Ezetimibe is a member of new class of lipid altering agents that inhibits the absorption of dietary and biliary cholesterol without affecting the absorption of triglycerides or fat soluble vitamins 7.
No clinically relevant drug-drug interactions have been associated with Ezetimibe administration, including statins. Combining Ezetimibe with a statin offers the theoretical advantage of incremental lipid lowering resulting from complementary mechanism of action Ezetimibe is orally active and potent with a unique mechanism of action that differs from other classes of cholesterol reducing compounds.
It localizes at the brush border of small intestine and inhibits the absorption of cholesterol, leading to a decrease in the intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol store and increase in clearance of cholesterol from the blood. Ezetimibe has no clinically meaningful effect on the plasma concentrations of the fat soluble vitamins and did not impair adrenocortical steroid hormone production.
The mean serum total cholesterol in rats at the start of the experiment zero week varies between The concentration of mean serum triglyceride, HDL-cholesterol, LDL-cholesterol in rats at the start of the experiment were between These findings were almost same as reported by Sankhala et al There was an increase in mean total cholesterol, mean triglyceride, mean LDL-cholesterol and a decrease in mean HDL-cholesterol in rats fed on atherogenic diet at 4 and 12 weeks.
This is comparable with the findings of Von Heek et al 8. Conde K et al observed similar findings in hypercholesterolemic guinea pigs receiving different doses of Atorvastatin High dose of Atorvastatin produced significant lowering of LDL cholesterol and total cholesterol without significantly affecting triglyceride and HDL-cholesterol; but high dose of Atorvastatin is associated with more chances of adverse effects.
Harry R et al observed similar findings in hypercholesterolemic dogs treated with different doses of Ezetimibe in combination with Atorvastatin These findings suggest that co-administration of Ezetimibe and Atorvastatin offers a highly efficacious new treatment option for patients with hypercholesterolemia.
Ezetimibe inhibits cholesterol absorption in the intestine. This inhibition is associated with compensatory increase in cholesterol synthesis. The observed increase in hepatic cholesterol synthesis might explain the favourable effect of co-administering Ezetimibe and statins according to a study by Davies HR Jr et al Take this medicine only as directed by your doctor.
Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.
This medicine comes with a patient information insert. Read and follow these instructions carefully. Ask your doctor if you have any questions. In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol.
Carefully follow your doctor's orders about any special diet. Swallow the tablet whole. Do not crush, break, chew, or dissolve it. You may take this medicine with or without food. Do not drink large amounts of alcohol with this medicine. This could cause unwanted effects on the liver. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep your medicine in the blister pack until you are ready to use it. After opening the blister pack, store it in a dry place and protect from moisture and light.
Once a tablet is removed, slide the blister card back into its folded card. It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Blood tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
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